Paper industry tests genetically altered trees

TAMPA, Fla. – The commercial paper industry\’s plans to plant forests of genetically altered eucalyptus trees in seven Southern states have generated more cries from critics worried that such a large introduction of a bioengineered nonnative plant could throw natural ecosystems out of whack.

ArborGen, a biotechnology venture affiliated with three large paper companies, got U.S. Department of Agriculture approval last month for field trials involving as many as 250,000 trees planted at 29 sites during the next few years. Much smaller lots of the genetically altered trees have been growing in some of the states for years.

Australian eucalyptus trees grow faster than native hardwoods and produce high-quality pulp perfect for paper production, but thus far, they have been able to thrive only in very warm climates. South Carolina-based ArborGen genetically altered the trees to withstand freezing temperatures, and the idea with the test forests is to see how far north they can now be grown.

The test sites will cover a total of about 300 acres in Florida, South Carolina, Texas, Alabama, Mississippi, Georgia and Louisiana.

While genetically engineered crops such as corn and soybeans have become common, ArborGen\’s experiment marks the first large planting of designer trees in the United States. The company says plantations of hearty, faster-growing eucalyptus could produce more timber in a smaller area and allow conservation of natural forests.

But critics say that despite the USDA\’s assurance that the trees pose no environmental threat, not enough is known about their effect on natural surroundings.

\”We have many reservations about it,\” said Neil J. Carman, a biologist who serves on the Sierra Club\’s genetic engineering committee. \”We don\’t think the scientific evidence is in yet that says this is a good idea.\”

Anne Petermann, executive director of the activist group Global Justice Ecology Project, said eucalyptus trees are invasive, require vast amounts of water that could reduce groundwater levels, and increase the wildfire risk because they are so flammable.

\”This is quite a dangerous tree to be mass planting,\” Petermann said.

But ArborGen CEO Barbara Wells said eucalyptus trees have not proven invasive in dozens of tropical countries where they are widely grown on plantations. Also, ArborGen genetically modified the trees to limit their ability to disperse seed and spread.

Although the new field trials will significantly increase the number of genetically engineered trees being grown, Wells called it \”very confined research.\”

\”The total is 300 acres, but when you\’re doing tree research, that really is very small acreage,\” she said, noting that about 20,000 acres of genetically unaltered eucalyptus trees are already grown in central and southern Florida for production of wood chips and mulch. The new test forests will show whether the genetically altered trees can thrive farther north in Florida, where freezing temperatures can occur in the winter.

Donald Rockwood, a professor emeritus in the University of Florida\’s School of Forest Resources and Conservation, has worked for about 30 years on developing eucalyptus trees that thrive in Florida. He uses traditional breeding techniques, not genetic modification.

The genetically unaltered trees growing in controlled plantations in Florida have not proven invasive, are relatively efficient users of water and are no more flammable than other hardwoods, said Rockwood, who was hired by ArborGen to do a report on eucalyptus trees\’ invasiveness because of his experience working with them at the university.

Still, Rockwood said, introduction of any genetically altered species poses risks. For example, the gene that makes the trees resistant to cold could be transferred to surrounding plants, allowing them to spread farther north than nature intended.

\”It certainly needs to be done carefully, it needs to be regulated and there needs to be a period of well-defined observations,\” Rockwood said.

The ArborGen trees will be planted in seven counties throughout Florida, four counties each in South Carolina and Texas, two each in Alabama and Mississippi and single counties in Georgia and Louisiana. Rockwood said they can grow about 25 feet per year and be ready to harvest in less than three years.

ArborGen is a joint venture of International Paper, MeadWestvaco and Rubicon Ltd.

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Drug boosts survival in major skin cancer study

CHICAGO – Researchers have scored the first big win against melanoma, the deadliest form of skin cancer. An experimental drug significantly improved survival in a major study of people with very advanced disease.

The results, reported Saturday at a cancer conference, left doctors elated.

\”We have not had any therapy that has prolonged survival\” until now, said Dr. Lynn Schuchter of the Abramson Cancer Center at the University of Pennsylvania, a skin cancer specialist with no role in the study or ties to the drug\’s maker.

The drug, ipilimumab, (ip-ee-LIM-uh-mab), works by helping the immune system fight tumors. The federal Food and Drug Administration has pledged a quick review, and doctors think the drug could be available by the end of this year.

\”People are going to have a lot of hope and want this drug, and it\’s not on their doctors\’ shelves,\” although some may be able to get it through special programs directly from its maker, Bristol-Myers Squibb Co., Schuchter said.

Melanoma is the most serious form of skin cancer. Last year in the United States, there were about 68,720 new cases and 8,650 deaths from the disease. Worldwide, more than 50,000 people die of melanoma each year.

\”The incidence is rising faster than any other cancer,\” said one of the study\’s leaders, Dr. Stephen Hodi of Dana-Farber Cancer Institute in Boston. \”When it spreads to vital organs, it\’s almost always fatal.\”

Doctors also reported Saturday at the conference that an experimental drug for lung cancer patients with a certain gene showed extraordinary promise in early testing. The drug, Pfizer Inc.\’s crizotinib, (crih-ZAH-tin-ib) targets a gene that promotes tumor growth and is found in about 4 percent of lung cancers, especially among younger, non-smokers.

Nearly 220,000 new cases of lung cancer are diagnosed each year in the United States alone, and it is the world\’s top cancer killer. Two other gene-targeted treatments, Tarceva and Iressa, help about 20,000 lung cancer patients annually in the U.S.

The skin cancer study involved 676 people around the world with advanced, inoperable melanoma who had already tried other treatments — a very grim situation. They were given one of three treatments: ipilimumab by itself, with another immune-stimulating treatment, or the immune-stimulating treatment alone.

After two years, 24 percent of those given the drug alone or in combination were alive, versus 14 percent of those given just the immune-stimulating treatment.

Average survival was 10 months with ipilimumab versus just more than six months for the others, which worked out to a 67 percent improvement in survival for those on the drug, said one of the study\’s leaders, Dr. Steven O\’Day of the Angeles Clinic and Research Institute in Los Angeles.

Doctors hope the drug can provide more benefit if given earlier in the course of the disease and to less sick patients.

Ten percent to 15 percent of patients on ipilimumab had serious side effects related to the drug\’s actions on the immune system. Most were treatable with high doses of steroids, but 14 deaths were thought to be related to the treatment. That\’s still far fewer than deaths due to the cancer.

The study was funded by Bristol-Myers and Medarex Inc., a company that co-developed the drug and was bought by Bristol-Myers last year. A spokeswoman said Bristol-Myers has not yet set a price for the drug, but similar treatments for other cancers cost several thousand dollars a month or more.

Results were reported at the American Society of Clinical Oncology\’s annual conference in Chicago and published online by the New England Journal of Medicine.

___

Online:

Cancer meeting: http://www.asco.org

National Cancer Institute: http://www.cancer.gov

New England Journal of Medicine: http://www.nejm.org

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Yahoo\’s site mirrors Facebook in latest facelift

SAN FRANCISCO – Yahoo Inc.\’s latest facelift will include a Facebook touchup.

As part of changes rolling out this week, Yahoo will import personal updates from Facebook\’s social network for users who want a bridge between two of the world\’s most popular websites. The Facebook link will need to be turned on by each Yahoo user.

The personal updates, known as a \”news feed\” in Facebook\’s parlance, will be available throughout Yahoo\’s website, including its front page and e-mail service. Other tools will empower people to automatically let their Facebook friends know what they are doing and saying on Yahoo services such as its photo-sharing site, Flickr.

The additional tie-ins follow through on a makeover that Yahoo announced late last year in an effort to make its website more compelling.

Although Yahoo still commands a worldwide Internet audience of nearly 600 million, people have been hanging around for progressively shorter periods during the past few years. One of the reasons is because people increasingly congregate on Facebook to share photos, video clips and music, discuss current events and bond with their families and friends.

Yahoo, based in Sunnyvale, Calif., is betting that more of its visitors will stay on its website if they can simultaneously monitor what\’s happening on Facebook. Keeping people on its site longer would give Yahoo more opportunities to sell online ads and revive its revenue growth after an extended slump that has sapped its earnings power and stock price.

Connecting with Facebook is just the first step in Yahoo\’s attempt to establish its website as a social hub. Later this summer, Yahoo intends to import personal updates posted on Twitter\’s short-messaging service. And by the end of the year, Yahoo will begin featuring widely played Internet games such as \”Farmville,\” \”Mafia Wars\” and \”Fishville,\” made by Zynga.

The increased emphasis on so-called \”social media\” could make Yahoo more susceptible to the privacy backlashes that have plagued Facebook in recent years. Yahoo is trying to ensure people don\’t inadvertently share any sensitive information by simplifying its privacy controls and urging visitors to review their settings.

As part of that process, Yahoo\’s identify control center has been renamed \”Yahoo Pulse.\” It had been called Yahoo Profiles since its October 2008 debut.

The Facebook alliance is just the latest example of Yahoo\’s growing reliance on partnerships since the company hired Silicon Valley veteran Carol Bartz 17 months ago.

Yahoo\’s search engine is in the process of adopting Microsoft Corp.\’s technology. And the company recently decided to rely on IAC/InterActiveCorp.\’s Match.com as its online dating service. Bartz is turning to outsiders to lower Yahoo\’s overhead and sharpen its focus on its strengths in online news, sports, finance, entertainment and e-mail.

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Yahoo\’s site mirrors Facebook in latest facelift

SAN FRANCISCO – Yahoo Inc.\’s latest facelift will include a Facebook touchup.

As part of changes rolling out this week, Yahoo will import personal updates from Facebook\’s social network for users who want a bridge between two of the world\’s most popular websites. The Facebook link will need to be turned on by each Yahoo user.

The personal updates, known as a \”news feed\” in Facebook\’s parlance, will be available throughout Yahoo\’s website, including its front page and e-mail service. Other tools will empower people to automatically let their Facebook friends know what they are doing and saying on Yahoo services such as its photo-sharing site, Flickr.

The additional tie-ins follow through on a makeover that Yahoo announced late last year in an effort to make its website more compelling.

Although Yahoo still commands a worldwide Internet audience of nearly 600 million, people have been hanging around for progressively shorter periods during the past few years. One of the reasons is because people increasingly congregate on Facebook to share photos, video clips and music, discuss current events and bond with their families and friends.

Yahoo, based in Sunnyvale, Calif., is betting that more of its visitors will stay on its website if they can simultaneously monitor what\’s happening on Facebook. Keeping people on its site longer would give Yahoo more opportunities to sell online ads and revive its revenue growth after an extended slump that has sapped its earnings power and stock price.

Connecting with Facebook is just the first step in Yahoo\’s attempt to establish its website as a social hub. Later this summer, Yahoo intends to import personal updates posted on Twitter\’s short-messaging service. And by the end of the year, Yahoo will begin featuring widely played Internet games such as \”Farmville,\” \”Mafia Wars\” and \”Fishville,\” made by Zynga.

The increased emphasis on so-called \”social media\” could make Yahoo more susceptible to the privacy backlashes that have plagued Facebook in recent years. Yahoo is trying to ensure people don\’t inadvertently share any sensitive information by simplifying its privacy controls and urging visitors to review their settings.

As part of that process, Yahoo\’s identify control center has been renamed \”Yahoo Pulse.\” It had been called Yahoo Profiles since its October 2008 debut.

The Facebook alliance is just the latest example of Yahoo\’s growing reliance on partnerships since the company hired Silicon Valley veteran Carol Bartz 17 months ago.

Yahoo\’s search engine is in the process of adopting Microsoft Corp.\’s technology. And the company recently decided to rely on IAC/InterActiveCorp.\’s Match.com as its online dating service. Bartz is turning to outsiders to lower Yahoo\’s overhead and sharpen its focus on its strengths in online news, sports, finance, entertainment and e-mail.

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Coke pays $715M to distribute Dr Pepper

ATLANTA – The Coca-Cola Co. says it will distribute certain drinks made by Dr Pepper Snapple Group Inc. as part of a $715 million deal.

The agreement was announced Monday morning.

Under the terms of the deal, Coca-Cola will distribute Dr Pepper and Canada Dry ginger ale in the U.S. It will also distribute drinks in Canada. Dr Pepper Snapple gets a one-time $715 million payment from Coca-Cola.

The beverages have been distributed by Coca-Cola Enterprises Inc., which Coca-Cola is acquiring. Monday\’s agreement replaces an established deal between Coca-Cola Enterprises and Dr Pepper.

The new agreement will last for 20 years and includes renewal options.

As part of the deal, Dr Pepper and Diet Dr Pepper will be included in Coke\’s new freestyle fountain dispenser.

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